Yes, you can use BrightSign media players with a Mac!
BrightSign HD220 players are perfect for displaying multichannel video work. (They sync over Ethernet and they’re cheaper and more reliable than Mac Minis running my MultiScreener software). Most people use the Windows-only BrightAuthor software to configure their players. I’ve collected some simple scripts that make it easy to set up the players without BrightAuthor.
(You can do it on Mac, Windows, or Linux).
Info and download here.